منابع مشابه
The Devil in the Details
1. Dean LS, Rogers RP 3rd, Harley RA, Hood DD: Case scenario: Amniotic fluid embolism. ANESTHESIOLOGY 2012; 116:186 –92 2. Annecke T, Geisenberger T, Kürzl R, Penning R, Heindl B: Algorithm-based coagulation management of catastrophic amniotic fluid embolism. Blood Coagul Fibrinolysis 2010; 21:95–100 3. Leighton BL, Wall MH, Lockhart EM, Phillips LE, Zatta AJ: Use of recombinant factor VIIa in ...
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The notion of “vulnerable atherosclerotic plaque” introduced many years ago1,2 has been since used frequently and liberally, including by this investigator.3 We generally use this phrase to refer to intact lesions that look similar to those previously found to be disrupted and complicated by thrombosis on pathological examination. In doing so, we assume that given enough time or the right stimu...
متن کاملQuantitative Dynamics of Phosphoproteome: The Devil Is in the Details
Recent advances in peptide-based (bottom-up) quantitative proteomics and bioinformatics have opened unprecedented opportunities for extensive investigation of cellular proteomes and their dynamics. Here we discuss two approaches currently used to investigate the global dynamics of phosphorylation based on the isolation of phosphorylated proteins or peptides. We evaluate the accuracy of these me...
متن کاملThe cost of reproduction: the devil in the details.
The cost of reproduction is of fundamental importance in life-history evolution. However, our understanding of its mechanistic basis has been limited by a lack of detailed functional information at all biological levels. Here, we identify, evaluate and integrate recent studies in five areas examining the proximate mechanisms underlying the cost of reproduction. Rather than being alternate expla...
متن کاملThe role of dispensaries: the devil is in the details.
INTRODUCTION Relying on results from Pacula et al. (2013), Pacula and Sevigny argue that medical marijuana dispensaries increase the consumption of marijuana, increase the consumption of alcohol, and lead to more alcohol-related traffic fatalities. Below, we will: • Argue that the dispensary indicator used by Pacula et al. (2013) is essentially unrelated to whether dispensaries were actually in...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2013
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4014